Language-independent talker-specificity in first-language and second-language speech production by bilingual talkers: L1 speaking rate predicts L2 speaking rate

Second-language (L2) speech is consistently slower than first-language (L1) speech, and L1 speaking rate varies within- and across-talkers depending on many individual, situational, linguistic, and sociolinguistic factors. It is asked whether speaking rate is also determined by a language-independent talker-specific trait such that, across a group of bilinguals, L1 speaking rate significantly predicts L2 speaking rate. Two measurements of speaking rate were automatically extracted from recordings of read and spontaneous speech by English monolinguals (n = 27) and bilinguals from ten L1 backgrounds (n = 86): speech rate (syllables/second), and articulation rate (syllables/second excluding silent pauses). Replicating prior work, L2 speaking rates were significantly slower than L1 speaking rates both across-groups (monolinguals' L1 English vs bilinguals' L2 English), and across L1 and L2 within bilinguals. Critically, within the bilingual group, L1 speaking rate significantly predicted L2 speaking rate, suggesting that a significant portion of inter-talker variation in L2 speech is derived from inter-talker variation in L1 speech, and that individual variability in L2 spoken language production may be best understood within the context of individual variability in L1 spoken language production

Clear speech perception in acoustic and electric hearing

When instructed to speak clearly for people with hearing loss, a talker can effectively enhance the intelligibility of his/her speech by producing "clear" speech. We analyzed global acoustic properties of clear and conversational speech from two talkers and measured their speech intelligibility over a wide range of signal-to-noise ratios in acoustic and electric hearing. Consistent with previous studies, we, found that clear speech had a slower overall rate, higher temporal amplitude modulations, and also produced higher intelligibility than conversational speech. To delineate the role of temporal amplitude modulations in clear speech, we extracted the temporal envelope from a number of frequency bands and replaced speech fine-structure with noise fine-structure to simulate cochlear implants. Although both simulated and actual cochlear-implant listeners required higher signal-to-noise ratios to achieve normal performance, a 3-4 dB difference in speech reception threshold was preserved between clear and conversational speech for all experimental conditions. These results suggest that while temporal fine structure is important for speech recognition in noise in general, the temporal envelope carries acoustic cues that contribute to the clear speech intelligibility advantage. (C) 2004 Acoustical Society of America

Growth-inhibitory effects of the chemopreventive agent indole-3-carbinol are increased in combination with the polyamine putrescine in the SW480 colon tumour cell line

BACKGROUND: Many tumours undergo disregulation of polyamine homeostasis and upregulation of ornithine decarboxylase (ODC) activity, which can promote carcinogenesis. In animal models of colon carcinogenesis, inhibition of ODC activity by difluoromethylornithine (DFMO) has been shown to reduce the number and size of colon adenomas and carcinomas. Indole-3-carbinol (I3C) has shown promising chemopreventive activity against a range of human tumour cell types, but little is known about the effect of this agent on colon cell lines. Here, we investigated whether inhibition of ODC by I3C could contribute to a chemopreventive effect in colon cell lines. METHODS: Cell cycle progression and induction of apoptosis were assessed by flow cytometry. Ornithine decarboxylase activity was determined by liberation of CO(2 )from (14)C-labelled substrate, and polyamine levels were measured by HPLC. RESULTS: I3C inhibited proliferation of the human colon tumour cell lines HT29 and SW480, and of the normal tissue-derived HCEC line, and at higher concentrations induced apoptosis in SW480 cells. The agent also caused a decrease in ODC activity in a dose-dependent manner. While administration of exogenous putrescine reversed the growth-inhibitory effect of DFMO, it did not reverse the growth-inhibition following an I3C treatment, and in the case of the SW480 cell line, the effect was actually enhanced. In this cell line, combination treatment caused a slight increase in the proportion of cells in the G(2)/M phase of the cell cycle, and increased the proportion of cells undergoing necrosis, but did not predispose cells to apoptosis. Indole-3-carbinol also caused an increase in intracellular spermine levels, which was not modulated by putrescine co-administration. CONCLUSION: While indole-3-carbinol decreased ornithine decarboxylase activity in the colon cell lines, it appears unlikely that this constitutes a major mechanism by which the agent exerts its antiproliferative effect, although accumulation of spermine may cause cytotoxicity and contribute to cell death. The precise mechanism by which putrescine enhances the growth inhibitory effect of the agent remains to be elucidated, but does result in cells undergoing necrosis, possibly following accumulation in the G(2)/M phase of the cell cycle

Talker and background noise specificity in spoken word recognition memory

Prior research has demonstrated that listeners are sensitive to changes in the indexical (talker-specific) characteristics of speech input, suggesting that these signal-intrinsic features are integrally encoded in memory for spoken words. Given that listeners frequently must contend with concurrent environmental noise, to what extent do they also encode signal-extrinsic details? Native English listeners’ explicit memory for spoken English monosyllabic and disyllabic words was assessed as a function of consistency versus variation in the talker’s voice (talker condition) and background noise (noise condition) using a delayed recognition memory paradigm. The speech and noise signals were spectrally-separated, such that changes in a simultaneously presented non-speech signal (background noise) from exposure to test would not be accompanied by concomitant changes in the target speech signal. The results revealed that listeners can encode both signal-intrinsic talker and signal-extrinsic noise information into integrated cognitive representations, critically even when the two auditory streams are spectrally non-overlapping. However, the extent to which extra-linguistic episodic information is encoded alongside linguistic information appears to be modulated by syllabic characteristics, with specificity effects found only for monosyllabic items. These findings suggest that encoding and retrieval of episodic information during spoken word processing may be modulated by lexical characteristics

French Speech Segmentation in Liaison Contexts byL1 and L2 Listeners

In this study, we consider how native status and signal degradation influence French listeners’ segmentation of an incoming speech stream containing 'liaison', a phonological process that misaligns word and syllable boundaries. In particular, we investigate how both first language (L1) and second language (L2) French listeners compensate for the syllable-word misalignment associated with liaison while segmenting French speech, and whether compensation-for-liaison strategies differ with decreasing signal-to-noise ratios. We consider the degree to which listeners rely on lexical knowledge, acoustic-phonetic cues, and distributional information to accomplish this compensation. Listeners completed a word identification task in which they heard adjective-noun sequences with or without liaison and were presented with the word or nonword alternatives for each noun that would result depending on whether the listener did or did not compensate for liaison. Results showed that both L1-French and L2-French listeners generally preferred lexically acceptable parses over those that resulted in a stranded nonword, and both groups gave significantly fewer lexically acceptable parses under harder listening conditions. However, the L2-French listeners demonstrated a pattern of boundary placement that indicated over-compensation for liaison, suggesting that they had successfully acquired, but not fully constrained, rules about liaison

Language-independent talker-specificity in bilingual speech intelligibility: Individual traits persist across first-language and second-language speech

The present study provides evidence of a positive correlation between L1 and L2 intelligibility for bilingual talkers. Each talker in a group of Mandarin-English and Korean-English bilinguals was recorded producing simple sentences in each of their languages. The recordings were then presented to native listeners of the language-being-spoken in a test of sentence-in-noise recognition to yield a pair of L1 and L2 intelligibility scores for each talker based on the proportion of words correctly recognized. For all talkers, their L2 speech (i.e., Mandarin- or Korean-accented English) was consistently lower in intelligibility than their L1 speech (i.e., native accented Mandarin or Korean). This dissociation between L1-L2 speech intelligibility was evident in different intelligibility scores at comparable signal-to-noise ratios (as much as 35 percentage points for the Mandarin-English bilinguals) and in the required boost in signal-to-noise ratio to achieve comparable intelligibility (>8–10 dB). Critically, L1 and L2 intelligibility scores within the bilingual talkers were strongly positively correlated: Talkers with relatively high intelligibility in L1 also achieved relatively high intelligibility in L2. These results indicate a persistent influence of talker-specific trait characteristics that combine with, rather than are overwhelmed by, language-specific and dominance-dependent influences in bilingual speech production